Figures
Loss of Wingless signaling near compartment boundaries disrupts adult intestinal visceral muscle development.
The long-range action of Wingless/Wnt at compartment boundaries is essential for the development of the adult intestinal epithelium and overlying visceral muscles. Overexpression of Notum, a Wingless inhibitor, in the epithelium at the midgut-hindgut boundary and the adjacent posterior midgut results in extensive breaks and branches in the overlying longitudinal muscles and loss of the striated banding pattern of circular muscles (image). Similar muscle defects result from Wingless tethering at the midgut-hindgut boundary. See Tian et al.
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Image Credit: Ai Tian.
Citation: (2019) PLoS Genetics Issue Image | Vol. 15(6) July 2019. PLoS Genet 15(6): ev15.i06. https://doi.org/10.1371/image.pgen.v15.i06
Published: July 1, 2019
Copyright: © 2019 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The long-range action of Wingless/Wnt at compartment boundaries is essential for the development of the adult intestinal epithelium and overlying visceral muscles. Overexpression of Notum, a Wingless inhibitor, in the epithelium at the midgut-hindgut boundary and the adjacent posterior midgut results in extensive breaks and branches in the overlying longitudinal muscles and loss of the striated banding pattern of circular muscles (image). Similar muscle defects result from Wingless tethering at the midgut-hindgut boundary. See Tian et al.
Download June's cover page.
Image Credit: Ai Tian.