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Embryonic lethals impairing fertility in pigs.
Pigs are an excellent model to study harmful mutations causing embryonic lethality in homozygous affected individuals. In their study, Derks et al. identified five such recessive loci that impair the function of essential genes causing embryonic lethality in pigs. The lethal recessives affect up to 3% of the population litters, responsible for the death of 1 in 200 embryos. The study is intended to be used to lower the frequency of these harmful mutations to improve fertility in popular commercial pig breeds. See Derks et al.
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Image Credit: Anatolii Tsekhmister
Citation: (2019) PLoS Genetics Issue Image | Vol. 15(3) March 2019. PLoS Genet 15(3): ev15.i03. https://doi.org/10.1371/image.pgen.v15.i03
Published: March 31, 2019
Copyright: © 2019 Tsekhmister. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pigs are an excellent model to study harmful mutations causing embryonic lethality in homozygous affected individuals. In their study, Derks et al. identified five such recessive loci that impair the function of essential genes causing embryonic lethality in pigs. The lethal recessives affect up to 3% of the population litters, responsible for the death of 1 in 200 embryos. The study is intended to be used to lower the frequency of these harmful mutations to improve fertility in popular commercial pig breeds. See Derks et al.
Download March's cover page.
Image Credit: Anatolii Tsekhmister