Figures
DNA repair during meiosis and chromosomal bridges.
Meiotic cells respond to DNA damage triggering diverse repair mechanisms in a cell cycle-dependent manner. Sequential activation of these mechanisms contribute to accurately maintain genome integrity. However, when spermatocytes are exposed to exogenous DNA damaging agents, like gamma radiation, repair homeostasis may be stressed and chromosomes sometimes engage in aberrant connections with non-homologous chromosomes. Super-resolution fluorescence image (STED) of two meiotic bivalents labelled with an antibody against the SYCP3 protein of the synaptonemal complex. Parallel lines represent the trajectory of homologous chromosomes within each bivalent. A protein filament bridges from one bivalent to the other, connecting two non-homologous chromosomes. See Enguita-Marruedo et al.
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Image Credit: Marta Martín-Ruiz
Citation: (2019) PLoS Genetics Issue Image | Vol. 15(1) January 2019. PLoS Genet 15(1): ev15.i01. https://doi.org/10.1371/image.pgen.v15.i01
Published: January 31, 2019
Copyright: © 2019 Martín-Ruiz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Meiotic cells respond to DNA damage triggering diverse repair mechanisms in a cell cycle-dependent manner. Sequential activation of these mechanisms contribute to accurately maintain genome integrity. However, when spermatocytes are exposed to exogenous DNA damaging agents, like gamma radiation, repair homeostasis may be stressed and chromosomes sometimes engage in aberrant connections with non-homologous chromosomes. Super-resolution fluorescence image (STED) of two meiotic bivalents labelled with an antibody against the SYCP3 protein of the synaptonemal complex. Parallel lines represent the trajectory of homologous chromosomes within each bivalent. A protein filament bridges from one bivalent to the other, connecting two non-homologous chromosomes. See Enguita-Marruedo et al.
Download January's cover page.
Image Credit: Marta Martín-Ruiz