Figures
Genetic screen for tumour suppressors that cooperate with oncogenic Ras.
This image presents an example of the secondary screen conducted in this study, where RNAi lines for the top 100 primary screen hits were tested for their ability to enhance dRas-V12 mediated overgrowth in the Drosophila adult eye. The image shows scanning electron micrographs of a wild-type Drosophila adult eye (left) and an ey-GAL4-driven dRas-V12 + Tsp29Fb-RNAi expressing Drosophila adult eye (right) showing extensive overgrowth. Samples were prepared and imaged by Dr Jan Manent on a JCM-6000 NeoScope scanning electron microscope at the La Trobe University LIMS Bioimaging Facility.
Image Credit: Dr Jan Manent and Prof Helena Richardson, La Trobe University, Melbourne, Victoria, Australia.
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Citation: (2018) PLoS Genetics Issue Image | Vol. 14(10) October 2018. PLoS Genet 14(10): ev14.i10. https://doi.org/10.1371/image.pgen.v14.i10
Published: October 31, 2018
Copyright: © 2018 Manent/Richardson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This image presents an example of the secondary screen conducted in this study, where RNAi lines for the top 100 primary screen hits were tested for their ability to enhance dRas-V12 mediated overgrowth in the Drosophila adult eye. The image shows scanning electron micrographs of a wild-type Drosophila adult eye (left) and an ey-GAL4-driven dRas-V12 + Tsp29Fb-RNAi expressing Drosophila adult eye (right) showing extensive overgrowth. Samples were prepared and imaged by Dr Jan Manent on a JCM-6000 NeoScope scanning electron microscope at the La Trobe University LIMS Bioimaging Facility.
Image Credit: Dr Jan Manent and Prof Helena Richardson, La Trobe University, Melbourne, Victoria, Australia.