Figures
Oas2 activation results in lactation failure.
Artist impression of localised lactation failure restricted to a mammary ductal branch while the remaining breast continues to lactate. Here, Oakes et al. show that mutation of Oas2 activated viral sensing within murine mammary glands and resulted in decreased milk protein synthesis, loss of proliferation, increased apoptosis and a robust interferon response. Activation of the Oas2 pathway could provide an evolutionary conserved mechanism to prevent viral transmission via milk. See Oakes et al.
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Image Credit: Dr. Samantha R. Oakes. Pencil on paper.
Citation: (2017) PLoS Genetics Issue Image | Vol. 13(11) November 2017. PLoS Genet 13(11): ev13.i11. https://doi.org/10.1371/image.pgen.v13.i11
Published: November 30, 2017
Copyright: © 2017 Samantha Oakes. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Artist impression of localised lactation failure restricted to a mammary ductal branch while the remaining breast continues to lactate. Here, Oakes et al. show that mutation of Oas2 activated viral sensing within murine mammary glands and resulted in decreased milk protein synthesis, loss of proliferation, increased apoptosis and a robust interferon response. Activation of the Oas2 pathway could provide an evolutionary conserved mechanism to prevent viral transmission via milk. See Oakes et al.
Download November's cover page.
Image Credit: Dr. Samantha R. Oakes. Pencil on paper.