Figures
Challenging the Wnt signaling dogma.
Armadillo and Pangolin interaction represents the hallmark of the Wnt/Wingless (Wg) signaling response. Whether other interacting partners and alternative transcriptional complexes interfere with the canonical Wnt/Wg signaling pathway has long remained elusive. By applying large-scale quantitative genetic approaches, Franz et al. show that in Drosophila cells all Wnt/Wg signals proceed through Armadillo and Pangolin, and Wnt/Wg-responsive enhancers fully depend on the presence of Pangolin. The image shows the animals Armadillo and Pangolin on top of nucleotide sequences, illustrating their control over Wingless-responsive genes and enhancers. See Franz et al.
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Image Credit: Alexandra Franz
Citation: (2017) PLoS Genetics Issue Image | Vol. 13(4) April 2017. PLoS Genet 13(4): ev13.i04. https://doi.org/10.1371/image.pgen.v13.i04
Published: April 28, 2017
Copyright: © 2017 Alexandra Franz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Armadillo and Pangolin interaction represents the hallmark of the Wnt/Wingless (Wg) signaling response. Whether other interacting partners and alternative transcriptional complexes interfere with the canonical Wnt/Wg signaling pathway has long remained elusive. By applying large-scale quantitative genetic approaches, Franz et al. show that in Drosophila cells all Wnt/Wg signals proceed through Armadillo and Pangolin, and Wnt/Wg-responsive enhancers fully depend on the presence of Pangolin. The image shows the animals Armadillo and Pangolin on top of nucleotide sequences, illustrating their control over Wingless-responsive genes and enhancers. See Franz et al.
Download April's cover page here.
Image Credit: Alexandra Franz