Figures
Ppp6c deletion causes persistent DNA damage in oocytes within primordial follicles.
Pictured is the immunofluorescent staining of 2-month-old ovarian sections showing increased γH2AX in PP6c-depleted oocytes. Blue is DAPI stain. Green is immunofluorescence signal of γH2AX, a marker of DNA double strand breaks. Red is immunofluorescence signal of MVH (mouse VASA homolog), a germ cell marker. Using a genetically modified mouse model with specific deletion of Ppp6c in oocytes from the primordial follicle stage, we show that PP6 plays a critical role in germ cell survival and follicular development by safeguarding the genomic integrity of prophase I-arrested oocytes. See Hu, Meng et al.
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Image Credit: Meng-Wen Hu
Citation: (2016) PLoS Genetics Issue Image | Vol. 12(12) December 2016. PLoS Genet 12(12): ev12.i12. https://doi.org/10.1371/image.pgen.v12.i12
Published: December 30, 2016
Copyright: © 2016 Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pictured is the immunofluorescent staining of 2-month-old ovarian sections showing increased γH2AX in PP6c-depleted oocytes. Blue is DAPI stain. Green is immunofluorescence signal of γH2AX, a marker of DNA double strand breaks. Red is immunofluorescence signal of MVH (mouse VASA homolog), a germ cell marker. Using a genetically modified mouse model with specific deletion of Ppp6c in oocytes from the primordial follicle stage, we show that PP6 plays a critical role in germ cell survival and follicular development by safeguarding the genomic integrity of prophase I-arrested oocytes. See Hu, Meng et al.
Download December's cover page here.
Image Credit: Meng-Wen Hu