Figures
Genetic roles of six7 in photoreceptor development.
Vision is highly dependent on the number and types of retinal photoreceptors and their arrangement. This image shows the asymmetric distribution of rod photoreceptors (yellow) in the cone-dominated larval zebrafish retina. The density of rods is highest in the ventral retina but rapidly declines in the central and dorsal retina. Exploiting photoreceptor patterning in zebrafish, Sotolongo-Lopez and colleagues reveal two independent functions of six7 in photoreceptor development. Their study shows that the asymmetric distribution of rods is regulated in a dosage dependent manner by the transcription factor six7, and that six7 is essential for survival of green-wavelength sensitive cone precursors. See Sotolongo-Lopez et al.
Image Credit: James M. Fadool and Karen Alvarez-Delfin
Citation: (2016) PLoS Genetics Issue Image | Vol. 12(4) April 2016. PLoS Genet 12(4): ev12.i04. https://doi.org/10.1371/image.pgen.v12.i04
Published: April 29, 2016
Copyright: © 2016 Fadool and Alvarez-Delfin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vision is highly dependent on the number and types of retinal photoreceptors and their arrangement. This image shows the asymmetric distribution of rod photoreceptors (yellow) in the cone-dominated larval zebrafish retina. The density of rods is highest in the ventral retina but rapidly declines in the central and dorsal retina. Exploiting photoreceptor patterning in zebrafish, Sotolongo-Lopez and colleagues reveal two independent functions of six7 in photoreceptor development. Their study shows that the asymmetric distribution of rods is regulated in a dosage dependent manner by the transcription factor six7, and that six7 is essential for survival of green-wavelength sensitive cone precursors. See Sotolongo-Lopez et al.
Image Credit: James M. Fadool and Karen Alvarez-Delfin