Figures
Building invadopodia in vivo
Invadopodia are small F-actin rich, membrane associated structures that invasive cells use in development and cancer to breach basement membrane barriers to enter tissues. Shown here is the Caenorhabditis elegans anchor cell (cyan) invading across the basement membrane (magenta) and entering the vulval tissue. Using anchor cell invasion, we conducted the first genome-wide screen for genes that regulate invadopodia in vivo and reveal that the small GTPase cdc-42 seeds new invadopodia, while the guanine dissociation inhibitor gdi-1 controls the trafficking of the specialized invadopodial membrane to sites of invadopodia construction. See Lohmer, Clay et al.
Image Credit: Matthew Clay, Sherwood Lab, Duke University
Citation: (2016) PLoS Genetics Issue Image | Vol. 12(1) January 2016. PLoS Genet 12(1): ev12.i01. https://doi.org/10.1371/image.pgen.v12.i01
Published: January 29, 2016
Copyright: © 2016 Matthew Clay. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Invadopodia are small F-actin rich, membrane associated structures that invasive cells use in development and cancer to breach basement membrane barriers to enter tissues. Shown here is the Caenorhabditis elegans anchor cell (cyan) invading across the basement membrane (magenta) and entering the vulval tissue. Using anchor cell invasion, we conducted the first genome-wide screen for genes that regulate invadopodia in vivo and reveal that the small GTPase cdc-42 seeds new invadopodia, while the guanine dissociation inhibitor gdi-1 controls the trafficking of the specialized invadopodial membrane to sites of invadopodia construction. See Lohmer, Clay et al.
Image Credit: Matthew Clay, Sherwood Lab, Duke University