Figures
Transcription factors control comb development in chickens.
There are three comb types in chickens that are each inherited independently as single gene traits: Rose, Pea and Duplex comb. Here the Duplex V-Shaped phenotype is shown to be caused by ectopic expression of the transcription factor Eomesodermin (EOMES). Previous reports have shown Rose and Pea comb to be caused by ectopic expression of transcription factors MNR2 and SOX5, respectively. Remarkably, the causal mutations for all three comb types represent structural genomic variants (duplications and inversions) that disrupt normal expression of these transcription factors and result in vastly different developmental outcomes for the comb. See Dorshorst et al.
Image Credit: Ben Dorshorst and colleagues
Citation: (2015) PLoS Genetics Issue Image | Vol. 11(3) March 2015. PLoS Genet 11(3): ev11.i03. https://doi.org/10.1371/image.pgen.v11.i03
Published: March 31, 2015
Copyright: © 2015 Dorshorst et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
There are three comb types in chickens that are each inherited independently as single gene traits: Rose, Pea and Duplex comb. Here the Duplex V-Shaped phenotype is shown to be caused by ectopic expression of the transcription factor Eomesodermin (EOMES). Previous reports have shown Rose and Pea comb to be caused by ectopic expression of transcription factors MNR2 and SOX5, respectively. Remarkably, the causal mutations for all three comb types represent structural genomic variants (duplications and inversions) that disrupt normal expression of these transcription factors and result in vastly different developmental outcomes for the comb. See Dorshorst et al.
Image Credit: Ben Dorshorst and colleagues