Figures
Drinking from the cup of adaptive landscapes: modeling a phenotypic fitness landscape of gene expression to predict epistasis between beneficial mutations.
This image shows a "landscape" carved into a 40-year old pottery mug made by the corresponding author's father. It is reminiscent of the metaphor of adaptive landscapes used to derive intuition about how populations evolve. We examined a series of strains with beneficial mutations affecting the expression of a metabolic pathway under selection. By developing a mathematical model based upon enzyme catalysis and costs of expression – parameterized to single mutants – we could predict the often antagonistic effects of combining beneficial mutations that were individually beneficial. See Chou et al.
Image Credit: Christopher J. Marx
Citation: (2014) PLoS Genetics Issue Image | Vol. 10(2) February 2014. PLoS Genet 10(2): ev10.i02. https://doi.org/10.1371/image.pgen.v10.i02
Published: February 27, 2014
Copyright: © 2014 Chou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This image shows a "landscape" carved into a 40-year old pottery mug made by the corresponding author's father. It is reminiscent of the metaphor of adaptive landscapes used to derive intuition about how populations evolve. We examined a series of strains with beneficial mutations affecting the expression of a metabolic pathway under selection. By developing a mathematical model based upon enzyme catalysis and costs of expression – parameterized to single mutants – we could predict the often antagonistic effects of combining beneficial mutations that were individually beneficial. See Chou et al.
Image Credit: Christopher J. Marx