Figures
Diversity in lung metastasis.
The lungs are the most common site of breast cancer metastasis. Metastatic efficiency is dictated by a complex interplay of tumor-intrinsic and host-derived factors. Allelic variability in the germline can be a major determinant of these factors, signifying that a heritable component contributes to an individual's propensity to develop metastatic disease. In this issue, Faraji et al. identify Cadm1 expression as a heritable metastasis susceptibility factor and show that tumor-intrinsic Cadm1 expression interacts with tumor-extrinsic T-cell–mediated immunity to modulate the efficiency of tumor cell metastasis to the lungs.
Image Credit: Farhoud Faraji and Thomas Geiger.
Citation: (2012) PLoS Genetics Issue Image | Vol. 8(9) September 2012. PLoS Genet 8(9): ev08.i09. https://doi.org/10.1371/image.pgen.v08.i09
Published: September 27, 2012
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The lungs are the most common site of breast cancer metastasis. Metastatic efficiency is dictated by a complex interplay of tumor-intrinsic and host-derived factors. Allelic variability in the germline can be a major determinant of these factors, signifying that a heritable component contributes to an individual's propensity to develop metastatic disease. In this issue, Faraji et al. identify Cadm1 expression as a heritable metastasis susceptibility factor and show that tumor-intrinsic Cadm1 expression interacts with tumor-extrinsic T-cell–mediated immunity to modulate the efficiency of tumor cell metastasis to the lungs.
Image Credit: Farhoud Faraji and Thomas Geiger.