Figures
Unresolved chromatin bridges during cytokinesis.
As with DNA double-strand breaks, uncapped telomere ends lead to the formation of dicentric chromosomes. These chromosome configurations may initiate genomic instability by firing BFB-cycles after chromatin bridges break during mitosis. However, some of these may remain unbroken (blue, DNA) during furrow ingression (yellow, cortical actin) up to later stages of cytokinesis. A study by Pampalona et al. in human mammary epithelial cells exhibiting progressive telomere dysfunction reports that persistent chromatin bridges in the cleavage plane engender binucleated polyploid cells by failing to complete cytoplasmatic cell division.
Image Credit: Judit Pampalona (Universitat Autònoma de Barcelona).
Citation: (2012) PLoS Genetics Issue Image | Vol. 8(4) April 2012. PLoS Genet 8(4): ev08.i04. https://doi.org/10.1371/image.pgen.v08.i04
Published: April 26, 2012
Copyright: © 2012 Pampalona. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
As with DNA double-strand breaks, uncapped telomere ends lead to the formation of dicentric chromosomes. These chromosome configurations may initiate genomic instability by firing BFB-cycles after chromatin bridges break during mitosis. However, some of these may remain unbroken (blue, DNA) during furrow ingression (yellow, cortical actin) up to later stages of cytokinesis. A study by Pampalona et al. in human mammary epithelial cells exhibiting progressive telomere dysfunction reports that persistent chromatin bridges in the cleavage plane engender binucleated polyploid cells by failing to complete cytoplasmatic cell division.
Image Credit: Judit Pampalona (Universitat Autònoma de Barcelona).