Figures
Iris transillumination defect of Lyst-mutant mice.
LYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles and is relevant to multiple human diseases. Lyst-mutant mice exhibit a variety of defects, including a unique pattern of concentric transillumination defects in the iris. In this issue of PLoS Genetics, Trantow et al. utilized iris phenotypes in a search for modifier genes that influence Lyst pathways. A priori, the expectation would have been that modifiers of Lyst would logically be related to organelle biogenesis. Instead, the authors show that at the level of the whole-animal, oxidative damage to membranes is a highly relevant event.
Image Credit: Michael Anderson
Citation: (2010) PLoS Genetics Issue Image | Vol. 6(7) July 2010. PLoS Genet 6(7): ev06.i07. https://doi.org/10.1371/image.pgen.v06.i07
Published: July 29, 2010
Copyright: © 2010 Michael Anderson. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
LYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles and is relevant to multiple human diseases. Lyst-mutant mice exhibit a variety of defects, including a unique pattern of concentric transillumination defects in the iris. In this issue of PLoS Genetics, Trantow et al. utilized iris phenotypes in a search for modifier genes that influence Lyst pathways. A priori, the expectation would have been that modifiers of Lyst would logically be related to organelle biogenesis. Instead, the authors show that at the level of the whole-animal, oxidative damage to membranes is a highly relevant event.
Image Credit: Michael Anderson