Figures
Silencing of the FMR1 Gene in Fragile X Mental Retardation Syndrome
Artistic representation of events occurring during gene silencing in Fragile X mental retardation syndrome (FXS). The FMR1 gene, which is on the X chromosome, colocalizes with a fragile site seen in FXS cells that gives this disorder its name. FXS alleles become associated with SIRT1. SIRT1, a class III histone deacetylase, deacetylates lysine 9 of histone H3 and lysine 16 of histone H4, ultimately leading to chromatin compaction and gene silencing (see Biacsi et al., e1000017).
Image Credit: Image by Dr. Marian L. Miller (Journal-Cover-Art.com).
Citation: (2008) PLoS Genetics Issue Image | Vol. 4(3) March 2008. PLoS Genet 4(3): ev04.i03. https://doi.org/10.1371/image.pgen.v04.i03
Published: March 28, 2008
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Artistic representation of events occurring during gene silencing in Fragile X mental retardation syndrome (FXS). The FMR1 gene, which is on the X chromosome, colocalizes with a fragile site seen in FXS cells that gives this disorder its name. FXS alleles become associated with SIRT1. SIRT1, a class III histone deacetylase, deacetylates lysine 9 of histone H3 and lysine 16 of histone H4, ultimately leading to chromatin compaction and gene silencing (see Biacsi et al., e1000017).
Image Credit: Image by Dr. Marian L. Miller (Journal-Cover-Art.com).