Table 1.
Characteristics of the three cohorts with genotype data, pre-COVID-19 datasets*.
Table 2.
Characteristics of the three analytical (unrelated, European ancestry) datasets*.
Fig 1.
Study-specific COVID-19 severity PRS PheWAS on pre-pandemic conditions in EUR individuals, unadjusted for BMI.
Study-specific PRS PheWAS results for MGI (top, 1694 PheCodes), All of Us (center, 1397 PheCodes), and UK Biobank (bottom, 1388 PheCodes) are shown. PheCodes are only labeled if they have reached nominal significance in one study and phenome-wide significance in another. To avoid overcrowding in the plot, for parent-sibling PheCode combinations, only the top PheCode is labeled. Summary statistics can be found in S3 Table. The dashed red line indicates the phenome-wide significance threshold, and the dashed yellow line indicates the nominal significance threshold. The upward/downward orientation of the triangles indicates the positive/negative direction of the estimated association.
Fig 2.
Study specific COVID-19 severity PRS PheWAS on pre-pandemic conditions in EUR individuals, adjusted for BMI.
Study-specific PRS PheWAS results for MGI (top, 1694 PheCodes), All of Us (center, 1397 PheCodes), and UK Biobank (bottom, 1388 PheCodes) are shown. PheCodes are only labeled if they have reached nominal significance in one study and phenome-wide significance in another. To avoid overcrowding in the plot, for parent-sibling PheCode combinations, only the top PheCode is labeled. Summary statistics can be found in S4 Table. The dashed red line indicates the phenome-wide significance threshold, and the dashed yellow line indicates the nominal significance threshold. The upward/downward orientation of the triangles indicates the positive/negative direction of the estimated association.
Fig 3.
Meta-analyzed COVID-19 severity PRS PheWAS on pre-pandemic conditions in EUR individuals.
A total of 1576 PheCodes that were analyzed in at least two studies are shown without (top) and with adjustment for BMI (bottom). PheCodes are only labeled if they have reached nominal significance in one analysis and phenome-wide significance in another. To avoid overcrowding in the plot, for parent-sibling PheCode combinations, only the top PheCode is labeled. Meta-analysis summary statistics can be found in S9 and S10 Tables. The dashed red line indicates the phenome-wide significance threshold, and the dashed yellow line indicates the nominal significance threshold. The upward/downward orientation of the triangles indicates the positive/negative direction of the estimated association.