Fig 1.
Maps of countries contributing data to the consortium.
Sample sizes (cases and controls) for each phenotype were added and represented on the logarithmic scale by each circle. Relative contribution to each phenotype is represented by the three colors. Maps obtained from https://www.naturalearthdata.com/.
Fig 2.
Participant’s genome projection on the first and second genetic principal components of the 1000G reference panel.
AFR: African ancestry. AMR: admixed American ancestry. EAS: east Asian ancestry. EUR: European ancestry. MID: middle eastern ancestry. SAS: south Asian ancestry.
Fig 3.
Single variant exome-wide association study Manhattan plot (MAF>0.1%).
QQ-plot available in the S1 Fig. Black dashed line demarcates the genome-wide significance threshold (p < 5x10-8).
Table 1.
Exome-wide significant findings, as well as other TLR7 results (for the severe phenotype only).
Note that for Masks M1, all deleterious variants had a MAF<0.1%, and hence both burden tests (MAF<1% and 0.1%) gave the same results. Full results available in S4 Table.
Fig 4.
Exome burden test ACAT p-value meta-analysis Manhattan plots and QQ plots.
QQ-plot available in the S6 Fig. Black dashed line demarcates the Bonferroni significance threshold (p < 0.5/20,000).
Fig 5.
Sex-stratified TLR7 analyses.
Table 2.
Results of burden tests at genes identified from common variants GWAS in the COVID-19 HGI.
Only genes with p<0.05/46 are shown here. Full results available in S8 Table.
Table 3.
Replication of M1 mask, severe COVID-19, MARK1 and TLR7 results in the GenOMICC cohort. Note that the same variants were included in both the MAF<1% and MAF<0.1% replication, and the same results were obtained (shown here).