Fig 1.
Domain structure of yeast Gcn5 compared to human GCN5 and PCAF homologs.
Functional domains of yeast yGcn5 and mammalian hGCN5 and hPCAF outlining E3 ligase, PCAF homology, acetyl transferase (HAT), and bromodomain (Brd) regions with known PTMs: phosphorylation (P), sumoylation (Su), ubiquitylation (Ub), acetylation (Ac), and methylation (M). Created with BioRender.com.
Table 1.
Posttranslational modifications of Gcn5-like acetyltransferases in yeast and mammalian cells.
Fig 2.
Molecular consequences for the modification of Gcn5 proteins.
Overview of cellular processes impacted by the modulation of Gcn5 proteins activities. For details, see indicated studies [35,36,39,53,58,63,64]. Adapted from “Circular Diagram with 8 Sections (Layout)”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates.