Fig 1.
Odds ratios for developing Alzheimer disease according to ApoE ε4/ε4 genotypes carriers relative to the ε3/ε3 carriers across the multiple ancestries.
Fig 2.
The regional plot of logistic regression analysis across the ApoE region for the interaction term.
Genomic coordinates are displayed along the X-axis. Negative logarithm of the association p-value for the interaction term is displayed on the Y-axis, with the red color representing markers that have FDR adjusted p-value < 0.05.
Table 1.
Effects of the rs10423769 genotype and its ApoE ε4 allele interaction terms in the logistic regression model across studies.
Fig 3.
The plot illustrates odds ratios for ε3/ε4 and ε4/ε4 genotypes relative to ε3/ε3 individuals in the combined African American and Ibadan individuals stratified by the rs10423769_A allele.
Subgroup odds ratios (95% CIs) are denoted by green color (circle) for rs10423769_A allele carriers and brown color (triangular) for no rs10423769_A allele carriers.
Table 2.
Odds Ratios for developing Alzheimer disease according to ApoE genotypes ε3/ε4 and ε4/ε4 relative to the ε3/ε3 stratified by the rs10423769_A allele and studies.
Fig 4.
The plot illustrates the Linkage Disequilibrium (LD) heatmap surrounding the rs10423769 variant.
The LD matrix was constructed based on r2(red color squares) and D′ (blue color squares) measurement for all pairs of variants. “Genes” panel illustrates the genes that are overlapping with the LD pattern.
Fig 5.
Chromatin Loops in chromosome 19 region centering on PSG2 and ApoE genes are displayed in four tracks, each representing one astrocyte line.
Induced pluripotent stem cells (iPSCs) with African (20–1611720 and LWHiC, top two tracks) or non-Hispanic White local ancestry (20–1616981 and 201–806023, bottom two tracks) were differentiated into astrocytes. Chromatin Hi-C library was constructed with 4-cutter enzyme. Blue vertical bar highlights rs10423769; yellow vertical bar highlights ApoE.
Table 3.
Characteristics of African American, Ibadan, Puerto Rican, and non-Hispanic White data sets.