Fig 1.
Workflow to screen for adhesion-related proteins involved in collective migration of Drosophila border cells.
BC migration in the developing egg chamber of Drosophila is known to be regulated by DE-cadherin [8]. Raza and collegues used ERC analysis to identify proteins with evolutionary rates correlated with DE-cadherin. This analysis ultimately led to the discovery of Raskol—a putative GTPase activating protein that regulates DE-cadherin and actin dynamics in multiple tissues, including BCs. BC, border cell; ERC, evolutionary rate covariance; RNAi, RNA interference.