Fig 1.
Illustration of local and global ancestry.
This figure represents chromosome 19 from Puerto Rican, African American, and European ancestry individuals. (A) The colored chromosomal segments represent the admixture blocks “local” to each genomic region, with each ancestry coded by a different color (red: African (AF), blue: European (EU), green: American Indian (AI)). (B) The global ancestry estimated by the average ancestry across the whole genome. The Puerto Rican individual has one African block and one European block around ApoE (represented by the dashed line); that is, the local ancestry around ApoE is African/European for this individual. The African American individual, though mostly African genome-wide, also has African/European local ancestry at the ApoE gene.
Table 1.
Haplotype analysis results, ApoE ε3 vs ApoE ε4, by cohort and haplotype local ancestry.
Fig 2.
Bonferroni corrected p-values for the pairwise comparisons of the allele frequencies in 1000 Genome sequence data between (A) CEU and YRI, and (B) JPT and YRI populations.
Red region represents topologically associated domain, containing ApoE.
Table 2.
Top list of the potential protective variants at the local ancestry blocks surrounding the ApoE gene.