Fig 1.
Study design schematic for discovery and replication of loci.
QC, quality control; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; HTN, hypertension; eQTL, expression quantitative loci.
Fig 2.
Regional plots of the significant loci A. TARID/TCF21 for SBP B. FRMD3 for SHet of CPASSOC C. LLPH locus for PP D. CDH17 for PP E. CDH17 for SHet of CPASSOC F. IGFBP3 for SHet of CPASSOC. The y axis shows the −log10 P values of SNP associations, and the x axis shows their chromosomal positions. The lowest P value SNP is plotted as a purple diamond and its correlation with other SNPs in the region is shown in color. The orange triangle is P value in the combined discovery and replication trans-ethnic meta-analysis of the lowest P value SNP.
Table 1.
Loci identified in combined COGENT-BP African ancestry discovery samples and multi-ethnic replication samples.
Fig 3.
Enrichment for functional annotations and cell-type groups using stratified LD score regression.
A. Enrichment estimates of 24 main annotations for each of four BP traits. Annotations are ordered by size. Error bars represent jackknife standard errors around the estimates of enrichment, and stars indicate significance at P < 0.05 after Bonferroni correction for 24 hypotheses tested and four BP traits. B. Significance of enrichment of 10 cell-type groups for four BP traits. Dotted line and stars indicate significance at P < 0.05 after Bonferroni correction for 10 hypotheses tested and four BP traits.
Fig 4.
Relative renal mRNA levels of genes identified at baseline and after 2 weeks of Ang II-induced hypertension.
HPRT gene was used for normalization. N ≥ 5 in each group. A. Genes that were differentially expressed between baseline and Ang II conditions. B. Genes that were not altered between the two conditions. * P < 0.05. ** P < 0.01. *** P < 0.001.