Figure 1.
A) Population fitness and B) fitness variance in the recombining and non-recombining populations over time.
Red and blue curves correspond to the mean value across 100 simulations in the recombining and non-recombining settings, respectively. Fitness and fitness variance values are normalized with the fitness of the reference sequence. The shaded regions show 95% confidence intervals. Parameters take values: and
.
Figure 2.
Effect of model parameters on the impact of recombination on adaptation.
Each bar corresponds to the relative fitness of the recombining to the non-recombining population at generation 100, measured by taking the logarithm (base 10) of the ratio of mean fitness of the recombining population to that of the non-recombining population and averaged across 100 simulations. The blue, green, orange and red bars correspond to population sizes and
, respectively. The error bars show the standard deviation of the difference between two log normal distributions (
). A) The effect of recombination rate at different population sizes for mutation rate:
. B) The effect of mutation rate at different population sizes for recombination rate:
. (The effect of recombination is still significant for populations larger than 103 with this recombination rate; see Figure S5).
Figure 3.
Contribution of the main and epistatic effects to the recombination effect on adaptation on the HIV-1 fitness landscape.
The x and y axes show the values of the constants by which the elements of the main and epistatic effects, respectively, are multiplied in the hierarchical fitness landscape. The plot shows the logarithm (base 10) of the ratio of mean fitness of the recombining to that of the non-recombining populations at generation 100, averaged across 100 simulations. Parameters take values: and
.
Figure 4.
Population epistasis of the HIV-1 fitness landscape.
A) An example of the log fitness plot against the Hamming distance between the reference sequence and sequences at generation 100 of one simulation for 20000 data points. Each point corresponds to one fitness value. To improve the visualization of the data on x axis, random values taken from a normal distribution with mean 0 and standard deviation 0.1 are added to the Hamming distances. The curvature of the red curved fitted to the data points defines population epistasis, which in this example is −0.0405. B) Distribution of population epistasis values across 500 simulations in the absence (blue) and presence (red) of recombination measured at generation 100. Parameters take values: and
.