Figure 1.
Predictive power of methylation and other genomic factors for CNV counts.
Predictive power of methylation, CpG island content, and repetitive element content (LINE, SINE, LTR, and Satellites) was measured using Akaike information criterion (AIC). For all five datasets, negative binomial regression was performed using all six factors and all six combinations of five factors (one factor being removed at a time). The y-axis represents the predictive power of a factor, as measured by the improvement of the AIC score based on all six factors relative to the AIC score without the factor. Note that this method measures predictive power of a factor after correction for any potential confounding due to other factors. (The detailed calculations and input data are in Supporting Information.)