Figure 1.
Mean-constant curves for height growth velocity between ages 8–16 y, estimated from the JPA-2 model (see Materials and Methods: Statistical Analyses), by sex and rs11107116 genotype (SOCS2 gene, Table S2).
Adult height increasing allele (T) is associated with higher PHV2 and earlier timing of pubertal height growth spurt.
Table 1.
Growth variables from longitudinal height data in NFBC1966 singletons with height SNP information, maximum N and mean (SD) given.
Table 2.
Associations between SNPs and adult height, peak height velocity in infancy (PHV1) and puberty (PHV2) and age at PHV2.
Figure 2.
Flow chart of genotyping strategy for the genetic association study on height growth in the NFBC1966.
The left arm shows genotyping done separately for 19 SNPs from Weedon et al, 2008 [4]; the right arm shows the GWA route to identify further 29 SNPs [5],[6]. The maximum number in final analyses was 3,538 with both growth and genotype information.