Figure 1.
Results of Genome-Wide Univariate and Multivariate Linkage Analyses
Results of univariate (red line) and multivariate (blue line) linkage analyses for absolute finger ridge count, showing empirical significant (dashed line) and suggestive (dotted line) thresholds for the univariate analysis obtained via simulation (1,000 replicates)
Figure 2.
Results of Univariate (Red Line) and Multivariate (Blue Line) Linkage Analyses for Absolute Finger Ridge Count on Chromosomes 1 (A) and 5 (B).
Empirical significant (thin red line) and suggestive (green line) thresholds for the univariate analysis obtained via simulation (1,000 replicates). Light blue dots indicate the 5-cM intervals at which linkage analyses were conducted. The inset graphs show the standardized path coefficients from the QTL factor from the multivariate analysis for each of the fingers. (Note: squaring the standardized path coefficients yields an estimate of the proportion of variance for each digit explained by the QTL.)
Table 1.
Linkage Regions Yielding LOD Scores over 1 (Bold), Change in Minus Twice Log-Likelihood (−2LL), LOD Scores the Standardized Path Coefficients (SPC) from the QTL Factors of the Univariate and Multivariate Genome Scans
Figure 3.
Univariate Variance Components Linkage Analyses for Individual Finger Ridge Count on Chromosome 5
Table 2.
Genetic and Environmental Standardized Path Coefficients from the Multivariate (Null) Model in Which the QTL Factor Loadings Were Set to Zero
Table 3.
Characteristics of Participants, Genotypic, and Phenotypic Data
Table 4.
Phenotypic Correlations between Absolute Ridge Count on Each Digit, Correlations between Homologous Digits in Bold
Figure 4.
Schematic Representation of the Additive and Dominant Genetic and QTL Factor Structures
The unique environmental factors structure (not shown) contained ten variables (using a full Cholesky decomposition). In the diagram below, color coding is used to indicate which parameters load on each digit, while horizontal arrays are used to indicate factor structure (e.g., the first additive genetic factor loads on all ten phenotypes, while factor 5 loads only on the little finger).