Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis
Fig 2
TP53 loss with oncogenic PIK3CA activation results in endometrial intraepithelial carcinoma.
a, Diagram of mouse alleles used in this study. b, Survival data of LtfCre0/+; (Gt)R26Pik3ca*H1047R; Trp53fl/fl (TP53/PIK3CA mutant) mice. Survival is measured as days to vaginal bleeding, requiring euthanasia. c, Representative H&E histology of control mouse endometrium from CRE-negative littermates. d, Representative H&E histology of endometrial intraepithelial carcinomas and hyperplastic epithelia in TP53/PIK3CA mutant uterus. Arrowheads denote dyplastic endometrial epithelia.