The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response
Fig 5
sei expression is specifically required in cholinergic, glutamatergic and octopaminergic neurons for response to acute heat stress.
Neuronal subtype specific RNAi-dependent sei knockdown screen. A-B) Cholinergic neurons (ChAT-GAL4) n = 12 vials/genotype; C-D) Glutamatergic neurons (VGlut-GAL4) n = 6; E-F) GABAergic neurons (Gad1-GAL4) n = 12; G-H) Octopaminergic neurons (Tbh-GAL4) n = 12; I-J) Dopaminergic neurons (ple-GAL4) n = 12; K-L) Serotonergic neurons (Trh-GAL4) n = 12; M-N) Peptidergic neurons (C929-GAL4) n = 6; O-P) Sensory neurons (PO163-GAL4) n = 6. All experiments conducted with 10 flies per vial, placed in 41–42°C water. Data are presented as mean ±SEM, **p < 0.01, ***p < 0.001 (Student’s t-test).