Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
Fig 5
Abnormal L1Hs mobilization in patients with Rett syndrome.
(A) Percentages of somatic L1Hs insertions in exons and introns. (B) Percentages of somatic L1Hs insertions in exons of long (> 100 kb) and short genes (< 100 kb). (C) Percentages of clonal somatic L1Hs insertions in introns. (D) Percentages of sense-oriented clonal somatic L1Hs insertions. The gray lines in (A) and (C) denoted the expected proportion determined by the exact base-pair count of that specific region relative to the human genome. The gray line in (D) represented the expected proportion if the insertions occurred randomly in both directions. Error bars in (A)–(D) indicated the 95% confidence intervals.