Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein
Fig 2
Depletion of UHRF2 reduces cell survival in response to ICL-causing agents.
A) Clonogenic survival assay of HeLa and HeLa UHRF2-/- cells in response to MMC. Depletion of UHRF2 reduces cell survival. Experiment was repeated 3 times, each with a p-value <0.01 at 2 ng/ml MMC. B) Clonogenic survival assay of HeLa and HeLa UHRF2 -/- cells in response to TMP/UVA. Depletion of UHRF2 reduces cell survival. Experiment was repeated 2 times, each with a p-value <0.01 at 80 J/m2. C) Clonogenic survival assay of HeLa and HeLa UHRF2-/- cells in response to UVC. Experiment was performed once in triplicate. D) Clonogenic survival assay of HeLa and HeLa UHRF2-/- cells in response to HU. Experiment was performed once in triplicate.