Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans
Fig 6
The defects of germ cell development in Wdr62−/− females were partially rescued by JNK1 overexpression.
Numerous MVH-positive germ cells and growing follicles were observed in (A) control (arrows) and (C) rescued ovaries (arrows) at P7, but not in (B) Wdr62−/− ovaries. (D) Quantification of germ cell numbers in control, rescued and Wdr62−/− ovaries at P7. Many corpora lutea (CL) were observed in (E) 8-week control (asterisks) and (G) rescued ovaries (asterisks) primed with PMSG and hCG, but not in (F) ovaries from Wdr62−/− mice. Live pups were obtained from (H) control and (I) rescued Wdr62−/− females via superovulation and embryo transplantation. Data are presented as the mean ± SEM. ns, p > 0.05, *p < 0.05; and **p < 0.01.