One for all and all for One: Improving replication of genetic studies through network diffusion
Fig 2
Filtering on network score improves replication rate.
The replication rate was computed for all genes surpassing the significance threshold for each GWAS. This procedure was repeated in each bootstrapped dataset and the average replication rate was determined (purple). This process was repeated using increasingly strict filters on the network diffusion scores. The baseline replication rate without utilizing network scores (naïve method) is represented by the purple points. The strictest network filter (red) has a consistently higher replication rate than the naïve method.