The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans
Fig 4
Removing GOT-1 transaminase restores bending in ubr-1 mutants.
A) A diagram depicting the structure of GOT-1 and the molecular lesion of the hp731 allele. B) GOT-1 is ubiquitously expressed in all somatic tissues. Scale bar 10μm. C) Mutations in got-1 suppress motor neuron defects in ubr-1. D) Restoring GOT-1 in premotor INs including AVE and RIM (blue line) in ubr-1; got-1 reverted curvature to that of ubr-1. *P<0.05, **P<0.01, ***P<0.001 by the Two-way RM ANOVA test. Data are represented as mean ± SEM.