New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages
Fig 2
IS6110 gene expression and determination of transposition dynamics in the MTBC.
(a) Total IS6110 expression in representative strains from the MTBC. Data are relative to BCG Pasteur. Columns and error bars are the average and standard deviation from three independent cultures. (b) IS6110 RFLP from MTBC strains analysed in panel (a). (c) IS6110 expression values normalised to the copy number content of this element. Columns represent normalised expression of IS6110 according to the left Y-axis. Red squares show the IS6110 copy number in each strain indicated in the right Y-axis. Normalised expression of BCG Pasteur is used as reference. (d) Expression per IS6110 copy relative to the copy number content in MTBC strains. Data fit with an exponential curve (r2 = 0.80) indicated by a grey shadowed line.