Modules of co-occurrence in the cyanobacterial pan-genome reveal functional associations between groups of ortholog genes
Fig 3
Genomic proximity of co-occurring CLOGs.
The average adjacency score (aAS) measures the co-localization of CLOGs grouped into co-occurring modules. (A) A histogram of the average adjacency score (aAS). The histogram shows a clear dichotomy between modules whose constituent CLOGs (and hence genes) are co-localized in all genomes (aAS ≈ 1) and modules whose genes are not co-localized (aAS ≈ 0). (B) A scatter plot between the similarity score, measuring the quality of co-occurrence, and the aAS. The plot indicates that there is a positive but weak correlation between the genomic proximity of the genes comprising a module (represented by the aAS) and the quality of co-occurrence. The straight line corresponds to a linear regression and serves as a guide to the eye. (C) A scatterplot between the number of CLOGs associated to module and the aAS. While larger modules tend to have a lower aAS, the aAS scores are relatively well distributed with respect to the number of CLOGs in a module. (D) A scatterplot between the number of strains associated to a a module and the aAS. The number aAS is again relatively well distributed with respect to number of participating strains. In both plots the straight line indicates a linear regression and serves as a guide to the eye.