Hereditary cancer genes are highly susceptible to splicing mutations
Fig 4
Enrichment of cancer genes in SSM-prone genes.
A. SSM versus all exonic mutations in the HGMD with regions of 99.9% confidence interval shown in gray. COSMIC cancer genes are highlighted in Red. MLH1, BRCA1, BRCA2, and NF1 are highlighted and labeled. B-C. Average percent of SSM or ESM in cancer genes versus non-cancer genes reported in HGMD. D. Average HI score of cancer genes in Upper, Expected, and Lower categories of genes.