BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis
Fig 5
BRDT contributes to the transcriptional silencing of the X chromosome in spermatocytes.
(A, B) Volcano plot representation of differentially expressed X-linked genes in Brdt-/- 17dpp (A) and 20dpp testes (B). The X axis represents the log fold-change (FC) in WT vs Brdt-/- spermatogenic cells. The Y axis represents the adjusted p-value. Only genes with an adjusted p-value of ≤0.05 were considered as differentially expressed genes (DEGs). (B, D) Number of X-linked genes with no change in expression, under-regulation or up-regulation in Brdt-/- 17dpp (B) and 20dpp (D) testes as compared to WT testes.