Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations
Fig 5
Predicted age of each mtDNA sequence.
Age calculations are based on the Rho. (A) Distribution of the mean pathogenicity scores of each mtDNA sequence and predicted age (Rho). Orange “x”: mtDNA sequence not carrying disease-causing mutations; Purple “x”: mtDNA sequence carrying disease-causing mutations. (B) Distribution of mean pathogenicity scores of each mtDNA sequence and predicted age (Rho) (C) Distribution of mtDNA sequences with disease-causing mutations according to predicted age (Rho). (D) Distribution of mtDNA sequences with non-disease-causing mutations according to predicted age (Rho).