Systems Genetic Analyses Highlight a TGFβ-FOXO3 Dependent Striatal Astrocyte Network Conserved across Species and Associated with Stress, Sleep, and Huntington’s Disease
Fig 2
Coexpression networks in the CN, CB, and CTX of a human HD cohort.
Topological overlap (TO) matrix plot depicts gene coexpression networks in (A) CN, (C) CB, and (E) CTX. (B,D,F) A comparison of TO matrices in cases (top right triangle) versus controls (bottom left triangle) for selected modules in each brain region. High TO (greater coexpression) is colored red, while low TO is colored white. Module differential connectivity (MDC) and FDR values are depicted for each module. Differential connectivity was considered significant by conservative thresholds (MDC > 2.0 or MDC < 0.5, FDR < 0.001). Three differentially connected modules and one conserved module are depicted for each brain region.