Comparative Genomic Analyses of the Human NPHP1 Locus Reveal Complex Genomic Architecture and Its Regional Evolution in Primates
Fig 5
Inter-species Miropeats alignments of primates to the human H2 SV haplotype.
A. Human reference build hg19 (H1). B. Chimpanzee (panTro4). C. Gorilla (gorGor3). D. Orangutan (ponAbe2). E. Macaque (rheMac3). F. Baboon (papAnu2). Above the top track in each Miropeats diagram is a depiction of the distribution of gaps (in grey) in the reference of nonhuman primates and a diagram of the genomic structure revealed by Miropeats. Below the bottom track in each Miropeats diagram is the diagram of H2 SV haplotype. Blue boxes, the human 358 kb LCRs or their orthologs in nonhuman primates; red boxes, the human 45 kb LCRs or their orthologs in nonhuman primates; yellow boxes, the human 5936Ins or its orthologs in nonhuman primates; green boxes, NPHP1 in each primate; grey boxes, gaps in the references. Blue traces, aligned sequences between the human 358 kb LCRs and their nonhuman orthologs; red traces, aligned sequences between the human 45 kb LCRs and their nonhuman orthologs; yellow traces, aligned sequences between the human 5936Ins and its nonhuman orthologs.