Mutations in MAB21L2 Result in Ocular Coloboma, Microcornea and Cataracts
Fig 5
Summary of TUNEL assays in zebrafish wild-type and mab21l2 mutant embryos.
TUNEL results in 24-hpf wild-type (A-B), mab21l2Q48Sfs*5 embryos (C-D) and mab21l2R51_F52del mutants (E-F) are shown. An increase in TUNEL staining was observed in both mab21l2 mutants with remarkably high levels in the mab21l2Q48Sfs*5 embryos, particularly in the lens and ventral retina (C-D), and moderately increased levels in the mab21l2R51_F52del embryos (E-F); arrowheads indicate sites of increased TUNEL staining in the eye and brain; le, lens; r, retina.