Genetic Analysis of Variation in Human Meiotic Recombination
Figure 5
Genomic regions that include the 6 most significant loci associated with recombination phenotypes.
(A–C) Maternal association results for SNPs from analysis of the AGRE samples (red) and combined AGRE and FHS samples (green) plotted for loci on chromosomes 10p.11.23 (A), 17q21.31 (B), and 1q21.1 (C). (D–F) Paternal association results for SNPs from analysis of the AGRE samples (blue) and combined AGRE and FHS samples (green) plotted for loci on chromosomes 4p16.3 (D), 9q31.3 (E), and 7q36.1 (F). The top panel of each figure highlights the most significant SNPs in the region. The center panel of each figure shows genes in each region, and direction of transcription. The bottom panel of each figure shows LD patterns at each locus, where black corresponds to stronger LD and light gray corresponds to weaker LD as shown in (C).