Lysine deficiency within a conserved lysine desert is critical for EEL-1/HUWE1 to support ubiquitin proteasome system function

• Katherine S. Yanagi,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-6221-3840

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• Brenda J. Chen,

  Roles Investigation

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

  ⨯
• Sheikh Omar Kunjo,

  Roles Investigation

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

  https://orcid.org/0009-0006-4646-9762

  ⨯
• Irini Topalidou,

  Roles Investigation, Writing – review & editing

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

  ⨯
• Nicolas Lehrbach

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nlehrbach@fredhutch.org

  Affiliation Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-7342-4136

  ⨯