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Open Access
Peer-reviewed
Research Article
Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner
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Tianjie Li,
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
Affiliations Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (MOE), Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Jingwei Li,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliations Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (MOE), Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Leyang Wang,
Roles Formal analysis, Writing – review & editing
Affiliations Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (MOE), Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Haiyan Huang ,
Roles Data curation, Formal analysis, Writing – review & editing
* E-mail: hy_huang@sjtu.edu.cn (HH); qiangwu@sjtu.edu.cn (QW)
Affiliations Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (MOE), Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Qiang Wu
Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing
* E-mail: hy_huang@sjtu.edu.cn (HH); qiangwu@sjtu.edu.cn (QW)
Affiliations Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (MOE), Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner
- Tianjie Li,
- Jingwei Li,
- Leyang Wang,
- Haiyan Huang,
- Qiang Wu
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- Published: July 16, 2026
- https://doi.org/10.1371/journal.pgen.1012242