A genomic-led strategy to anticipate drug safety effects

• Brian R. Ferolito ,

  Roles Conceptualization, Data curation, Methodology, Software, Writing – original draft, Writing – review & editing

  * E-mail: brian.ferolito@va.gov

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0003-3208-6446

  ⨯
• Andrea R. V. R. Horimoto,

  Roles Data curation, Methodology, Software, Writing – original draft

  Affiliation Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

  https://orcid.org/0000-0002-8573-5158

  ⨯
• Kai Gravel-Pucillo,

  Roles Conceptualization, Data curation, Software, Writing – review & editing

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  https://orcid.org/0009-0004-9754-9688

  ⨯
• Daniel J. Golden,

  Roles Data curation, Software, Writing – review & editing

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Hesam Dashti,

  Roles Conceptualization, Data curation

  Affiliation The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
• Claudia Giambartolomei,

  Roles Data curation

  Affiliations Health Data Science Centre, Human Technopole, Milan, Italy, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia, Genova, Italy

  https://orcid.org/0000-0003-2786-1225

  ⨯
• Danielle Rasooly,

  Roles Data curation

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-7715-1809

  ⨯
• Rachael Matty,

  Roles Project administration

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  ⨯
• Liam Gaziano,

  Roles Methodology

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, BHF Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0003-2059-8081

  ⨯
• Yakov Tsepilov,

  Roles Data curation

  Affiliation Open Targets Genetics, Open Targets, Hinxton, United Kingdom

  ⨯
• Lauren Costa,

  Roles Project administration

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  ⨯
• Nicole Kosik,

  Roles Project administration

  Affiliation Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0003-1384-7035

  ⨯
• Harris Ioannidis,

  Roles Data curation

  Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom

  https://orcid.org/0000-0003-3470-6055

  ⨯
• Mohd Karim,

  Roles Data curation

  Affiliation Genomic Discovery, Variant Bio, Seattle, Washington, United States of America

  ⨯
• Giovanna Winicki,

  Roles Writing – review & editing

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0009-0001-4977-9225

  ⨯
• Fiona Hunter,

  Roles Data curation

  Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom

  ⨯
• Claudia Langenberg,

  Roles Writing – review & editing

  Affiliations Precision Healthcare University Research Institute, Queen Mary University of London, London, United Kingdom, Computational Medicine, Berlin Institue of Health at Charit´e – Universitätsmedizin, Berlin, Germany, MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0002-5017-7344

  ⨯
• John C. Whittaker,

  Roles Methodology, Writing – review & editing

  Affiliation MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0002-3529-2379

  ⨯
• Million Veteran Program,

  Roles Project administration

  ⨯
• Tianxi Cai,

  Roles Resources

  Affiliation Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Gina M. Peloso,

  Roles Writing – review & editing

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Barbara Zdrazil,

  Roles Data curation, Methodology

  Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom

  https://orcid.org/0000-0001-9395-1515

  ⨯
• Maya Ghoussaini,

  Roles Data curation

  Affiliation Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, New York, United States of America

  ⨯
• Andrew R. Leach,

  Roles Data curation, Methodology

  Affiliation LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, United Kingdom

  ⨯
• Sumitra Muralidhar,

  Roles Resources

  Affiliation Department of Veterans Affairs, Office of Research and Development, Washington District of Columbia, United States of America

  ⨯
• Ines A. Smit,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom

  ⨯
• Juan P. Casas ,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors are last co-senior authors.

  Affiliation Biomarker Development/Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

  ⨯
• J. Michael Gaziano ,

  Roles Methodology

  ¶‡ These authors are last co-senior authors.

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Kelly Cho ,

  Roles Methodology

  ¶‡ These authors are last co-senior authors.

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
•  [ ... ],
• Alexandre C. Pereira

  Roles Conceptualization, Data curation, Methodology, Software, Writing – original draft, Writing – review & editing

  ¶‡ These authors are last co-senior authors.

  Affiliations Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, Massachusetts, United States of America, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-7782-5540

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