Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer’s disease and related dementias in a multi-site autopsy cohort

• Brenna Cholerton ,

  Contributed equally to this work with: Brenna Cholerton, Dana Godrich

  Roles Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Authors contributed equally

  Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

  https://orcid.org/0000-0002-2139-987X

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• Dana Godrich ,

  Contributed equally to this work with: Brenna Cholerton, Dana Godrich

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  ¶☯ Authors contributed equally

  Affiliation Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0002-3667-4694

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• Jeremy Pasteris,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0001-8933-002X

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• Joe Rivero,

  Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

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• Eden R. Martin,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  ⨯
• Brian W. Kunkle,

  Roles Data curation, Writing – review & editing

  Affiliations Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0002-9515-5157

  ⨯
• Adam C. Naj,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Kara L. Hamilton-Nelson,

  Roles Data curation, Project administration, Supervision, Writing – review & editing

  Affiliation John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0003-3748-7193

  ⨯
• Hui Wang,

  Roles Data curation, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0003-4043-5060

  ⨯
• Wan-Ping Lee,

  Roles Data curation, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Logan Dumitrescu,

  Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Vanderbilt Memory & Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  ⨯
• Timothy J. Hohman,

  Roles Conceptualization, Data curation, Investigation, Writing – review & editing

  Affiliations Vanderbilt Memory & Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  ⨯
• Richard Mayeux,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Taub Institute on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York City, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York City, New York, United States of America, Department of Neurology, College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York City, New York, United States of America, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America

  ⨯
• Eric B. Larson,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation Kaiser Permanente Washington Health Research Institute, Seattle, Washington, United States of America

  ⨯
• Paul K. Crane,

  Roles Data curation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Medicine, Division of General Internal Medicine, University of Washington, Harborview Medical Center, Seattle, Washington, United States of America

  ⨯
• C. Dirk Keene,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Caitlin S. Latimer,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Shubhabrata Mukherjee,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, United States of America

  ⨯
• Julia K. Kofler,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• M. Ilyas Kamboh,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliations Department of Human Genetics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

  ⨯
• David A. Bennett,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliation Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

  ⨯
• Laura Molina-Porcel,

  Roles Conceptualization, Data curation, Investigation, Resources, Writing – review & editing

  Affiliations Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Fundació Recerca Clínic Barcelona (FRCB), Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain, Neurological Tissue Bank of the Biobanc-Hospital Clínic-IDIBAPS, Barcelona, Spain

  https://orcid.org/0000-0003-4068-8578

  ⨯
• Michael Cuccaro,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  ⨯
• Margaret A. Pericak-Vance,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  ⨯
• Tatjana Rundek,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Neurology, Evelyn F. McKnight Brain Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America

  ⨯
• William K. Scott,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0001-9336-6404

  ⨯
• Walter Kukull,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Gerard Schellenberg,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Alzheimer’s Disease Genetics Consortium ,

  ¶Membership of the Alzheimer’s Disease Genetics Consortium is provided in the Acknowledgements

  ⨯
• Gary W. Beecham ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gary.beecham@wfusm.edu

  Affiliation Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

  https://orcid.org/0000-0002-7061-6332

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•  [ ... ],
• Thomas J. Montine

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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