Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation

• Buse Cınar Cakmak,

  Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Microbiology, Leibniz Universität Hannover, Hannover, Germany

  https://orcid.org/0000-0002-4270-4378

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• Johanna D. Saric,

  Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Microbiology, Leibniz Universität Hannover, Hannover, Germany

  https://orcid.org/0000-0002-5527-5381

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• Katrin Wrede,

  Roles Methodology, Writing – review & editing

  Affiliation Institute of Microbiology, Leibniz Universität Hannover, Hannover, Germany

  https://orcid.org/0009-0004-0745-0159

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• Neil A. Holmes,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom of Great Britain and Northern Ireland

  https://orcid.org/0000-0002-4979-9680

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• Julian Haist,

  Roles Methodology

  Current address: Tilray Deutschland GmbH, Densborn, Germany

  Affiliation Department of Biology/Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany

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• Maria A. Schumacher,

  Roles Visualization, Writing – review & editing

  Affiliation Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, United States of America

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• Mark J. Buttner,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom of Great Britain and Northern Ireland

  https://orcid.org/0000-0002-3505-2981

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• Natalia Tschowri

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: tschowri@ifmb.uni-hannover.de

  Affiliation Institute of Microbiology, Leibniz Universität Hannover, Hannover, Germany

  https://orcid.org/0000-0002-4304-1860

  ⨯