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Tissue-specific transfer learning improves functional variant and therapeutic target discoveries in breast and prostate cancer
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Qing Li ,
Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing
* E-mail: qing.li@vumc.org (QL); xingyi.guo@vumc.org (XG); quan.long@ucalgary.ca (QL)
Affiliations Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Canada
⨯ -
Dinghao Wang,
Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Mathematics and Statistics, University of Calgary, Calgary, Canada
⨯ -
Zilong Zhang,
Roles Data curation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Canada
⨯ -
Deshan Perera,
Roles Data curation, Formal analysis, Methodology, Writing – original draft
Affiliation Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Canada
⨯ - Zhishan Chen,
- Wanqing Wen,
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M. Ethan MacDonald,
Roles Writing – original draft, Writing – review & editing
Affiliations Department of Electrical & Software Engineering, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Canada, Department of Biomedical Engineering, University of Calgary, Calgary, Canada, Department of Radiology, University of Calgary, Calgary, Canada
⨯ -
Weijia Cai,
Roles Writing – original draft, Writing – review & editing
Affiliations Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯ - Jun Yan,
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Xiao-Ou Shu,
Roles Resources, Writing – original draft
Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯ -
Wei Zheng,
Roles Resources, Writing – original draft
Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯ - Xingyi Guo ,
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Quan Long
Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: qing.li@vumc.org (QL); xingyi.guo@vumc.org (XG); quan.long@ucalgary.ca (QL)
Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Canada, Department of Mathematics and Statistics, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Canada, Department of Medical Genetics, University of Calgary, Calgary, Canada
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https://orcid.org/0009-0005-1327-4347
Tissue-specific transfer learning improves functional variant and therapeutic target discoveries in breast and prostate cancer
- Qing Li,
- Dinghao Wang,
- Zilong Zhang,
- Deshan Perera,
- Zhishan Chen,
- Wanqing Wen,
- M. Ethan MacDonald,
- Weijia Cai,
- Jun Yan,
- Xiao-Ou Shu
- Published: May 6, 2026
- https://doi.org/10.1371/journal.pgen.1012145