Oocyte vitrification disrupts zygotic genome activation in embryos by impairing maternal spliceosome translation and Crxos splicing

• Jianpeng Qin ,

  Contributed equally to this work with: Jianpeng Qin, Ao Ning, Jian Han

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  https://orcid.org/0000-0002-4076-9776

  ⨯
• Ao Ning ,

  Contributed equally to this work with: Jianpeng Qin, Ao Ning, Jian Han

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  https://orcid.org/0009-0001-3979-5184

  ⨯
• Jian Han ,

  Contributed equally to this work with: Jianpeng Qin, Ao Ning, Jian Han

  Roles Conceptualization, Data curation, Methodology, Validation, Writing – original draft

  Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

  ⨯
• Xiangyi Chen,

  Roles Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  ⨯
• Beijia Cao,

  Roles Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  ⨯
• Yujun Yao,

  Roles Validation

  Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

  ⨯
• Xiaoqing He,

  Roles Investigation

  Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

  ⨯
• Bo Pan,

  Roles Formal analysis, Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  ⨯
• Yaozong Wei,

  Roles Formal analysis, Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  https://orcid.org/0009-0006-7509-2132

  ⨯
• Kunlin Du,

  Roles Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  ⨯
• Shuqi Zou,

  Roles Investigation

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  https://orcid.org/0009-0003-7922-4305

  ⨯
• Jiangfeng Ye,

  Roles Project administration

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  ⨯
• Guozhi Yu,

  Roles Conceptualization, Methodology

  Affiliation College of Life Science, Sichuan Agricultural University, Ya#39;an, China

  https://orcid.org/0000-0002-4319-3661

  ⨯
• Qiuxia Liang,

  Roles Conceptualization, Methodology

  Affiliation College of Life Science, Sichuan Agricultural University, Ya#39;an, China

  ⨯
• Jie Qiao,

  Roles Resources

  Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

  ⨯
• Jie Yan ,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  * E-mail: yanjiebjmu@bjmu.edu.cn (JY), zguangbin@sicau.edu.cn (GZ)

  Affiliation Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China

  ⨯
•  [ ... ],
• Guangbin Zhou

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  * E-mail: yanjiebjmu@bjmu.edu.cn (JY), zguangbin@sicau.edu.cn (GZ)

  Affiliation State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China

  https://orcid.org/0000-0002-4493-8311

  ⨯
• [ view all ]
• [ view less ]