The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction

• Michal Sadowski ,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: michalsadowski@ucla.edu (MS); rborder@cs.cmu.edu (RB)

  Affiliation Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-5998-0432

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• Andy W. Dahl,

  Roles Writing – review & editing

  Affiliation Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

  https://orcid.org/0000-0001-6520-4766

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• Noah Zaitlen ,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  ¶☯ These authors contributed equally.

  Affiliations Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America, Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America, Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Richard Border

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: michalsadowski@ucla.edu (MS); rborder@cs.cmu.edu (RB)

  ¶☯ These authors contributed equally.

  Affiliation Department of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-6293-2968

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